Research and Clinical Studies on Hoodia

History of Hoodia

The Bushmen of South Africa have been consuming Hoodia Gordonii for thousands of years to control hunger during their long hunting trips. Incredibly, these people have been able to go days without eating and still remain strong and energetic after consuming Hoodia.

It is not until the mid 60’s that the first research was done on Hoodia as an appetite suppressant. Even then, it took another 30 years for South African laboratories to isolate the active appetite suppressing ingredient in Hoodia. This ingredient was called P57 and was licensed to the British pharmaceutical company - Phytopharm.

A pharmaceutical company, Pfizer learnt about Hoodia and expressed its keen interest in developing a Hoodia drug. In 1998, Phytopharm sub-licensed the rights to develop p57 to Pfizer for $21 million. Pfizer returned the rights of Hoodia to Phytopharm and the latter is now working with Unilever.
First animal study

Research on Hoodia is sparse. A 2004 study conducted by Brown University Medical School on Zucker rats (Zucker rats are special rats bred to be obese and diabetic). Injections of P57 were given into the appetite centre of rat brains. It resulted in altered levels of ATP. The rats that received Hoodia ate less, lost weight and even saw some reversal of diabetes. Anything that can stop a rat from eating is very significant! However, this was an animal study and injections in the brain are different from oral consumption, so it cannot be used to show that oral Hoodia can suppress appetite in humans.

First human trial

The first human clinical trial was conducted by Phytopharm in which volunteers were chosen from Leicester, England, and placed in a “phase 1 unit”. It was a place that had features as close to prison as it gets. Half the group was given Hoodia and the other half was given a placebo.

The results showed that there was a statistically significant reduction in caloric intake and body fat levels in the P57 group. No adverse side effects were reported in the P57 group. At the end of 15 days, the group on Hoodia had reduced their food intake by 1000 calories a day. These results our significant if one bears in mind that an average man consumes around 2,600 calories a day and a woman about 1,900. Thus, this trial study showed that the hoodia gordonii extract reduces hunger or curbs appetite.

What’s expected in future?

In 2006, Unilever announced that they were able to successfully extract Hoodia’s active ingredient in a form that could be marketed to the public. Human research trials are now ongoing and Unilever expects that a product with the active Hoodia extract will be available in 2008.

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Weight Loss Pills - Why Choose Hoodia Diet Pills For Effective Weight Loss?

Weight loss pills are one of the most popular methods of reducing weight amongst overweight people across the world. Most obese people who find it tough to maintain an exercise regimen or introduce low-cal healthy diet in their sedentary lifestyle take resort to weight loss pills with a desire to easily and quickly shed their extra pounds.

With obesity rising by the day and becoming a major cause of concern, demand for weight loss pills is increasing at a phenomenal rate. One needs to be very cautious while selecting a weight loss pill as the market is flooded with fake weight loss pills that only lighten your wallet. In addition, one needs to keep in mind that even using a genuine and effective weight loss pill without a complementing, lifestyle changing weight loss program significantly reduces your chances of effective weight loss.

Let’s see how weight loss pills work.

Weight loss pills, both prescription and OTC, try to find ways to introduce a gap between calorie intake and calorie expenditure. We can further group them according to their action as;
Carbs, Starch or Fat Inhibitors,
Fat Burners
Appetite Suppressants.

Appetite suppressants are probably the more successful of the other OTCs. Popular appetite suppressants try to play down your appetite for food. They may get to act on the nervous system to deter hunger signals from being translated as a need for food. A popular appetite suppressant that has almost created a sensation in the weight world is the Hoodia weight loss pills. Purely herbal in nature with no known side effects, Hoodia is the preferred weight loss pill when one needs to curb excessive hunger - the root cause of weight gain.

Hoodia Weight Loss Pills
Hoodia weight loss pills are an all natural weight loss supplement derived from the Hoodia Gordonii plant, a rare succulent that grows in the extreme climate of Kalahari Desert in South Africa. Hoodia’s effectiveness as an appetite suppressant was even featured in Oprah Winfrey and the 60 Minutes show. The demand for this gentle and effective weight loss pill has only been soaring since then.

The peculiarity of the cactus-like Hoodia Gordonii plant is that it contains what is called an appetite suppressant P57 molecule. The native San Bushmen tribe has for generations been using the unique property of Hoodia Gordonii as a natural appetite suppressant and thirst quencher during their long hunting trips in Kalahari.

The active P57 molecule in Hoodia Gordonii targets the hypothalamus region in the brain, which controls the sensation of thirst and hunger. When you eat, the glucose level in your body rises, and the nerve cells in the hypothalamus respond, letting you know that you no longer need to eat. The exciting thing about the P57 molecule is that it copies the effect that glucose has on the brain. The P57 molecule goes to the mid-brain and makes the nerve cells fire as if you were full, causing you to want to eat less.

Hoodia Diet Pills
In this world where obesity is emerging as the leading cause of mortality, Hoodia diet pills is seen as a miracle supplement that can help you control weight by suppressing appetite. Most other diet pills and products in the market require greater conscious and more intentional efforts to control weight while Hoodia diet pills requires least effort to achieve the desired results.

Regular intake of Hoodia diet pills can help you reduce calorie intake by 2000 calories per day. All you need to do is take 1-3 Hoodia diet pills an hour before your meal, three times a day. Combined with regular exercise and a healthy diet, Hoodia diet pills will help you shed unwanted pounds easily. Pure Hoodia diets pills are 100 % natural and have no known side effects.

However, excessive popularity of Hoodia Gordonii has generated huge demand for Hoodia diet pills to the extent that a protected status had to be imposed on Hoodia Gordonii plant. There are many fake products in the market claiming to contain pure Hoodia but all these products do not actually contain the active ingredient alleged to suppress appetite. Many companies use the skin, spines etc of the Hoodia plant which does not offer any benefit, but only increases the percentage weight of Hoodia. One needs to know that it is only the ‘heart’ of the Hoodia that has the appetite suppressant P57 molecule.

Please make sure that the Hoodia diet pill that you are buying is pure and genuine by carefully checking the label. A pure Hoodia diet pill carries a certificate of analysis, random analysis testing certificate and a certificate by CITES (Convention on the International Trade in Endangered Species of the Worlds Fauna and Wildlife) to ensure legal export of product from South Africa.

By: Shaily brown

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Shaily is one of the good article writers having much experience in writing health articles. She has written this article on slimming pills and herbal weight loss pills like Hoodia for weight loss treatment.

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Review On Hoodia Diet Pills

Hoodia is a genus of thirteen species in the flowering plant Apcynaceae family, which is under the subfamily Asclepiadoideae. Hoodia plants are trunk succulents, which are also known as Cactiform because of the significant similarity between them and the unconnected cactus family. Their height can be a maximum of 1m and they have big flowers which often have strong smell and flesh color. A lot of hoodia plants are secured plants, ranging to southern Angola from Central Namibia, in rocky areas and plains in particular. Some of those species are treated as garden plants and one of those, Hoodia Gordonii, is now under investigation for using it as an appetite suppressant.

Hoodia gordonii diet pills, products and liquids are now very effective due to the Hoodia Breakthrough. Just because of that, losing weight is more effective and much safer now-a-days with all natural pure Hoodia diet pills and liquids. Some of the Hoodia Gordonii products are Pure Hoodia Diet Pills, Hunger Block Plus Diet Pills, Hoodia Liquid, Hoodia Comb packs etc. These are now famous throughout the globe because of their effectiveness and safety.

Many people are afraid of diet pills because diet pills usually have scary side effects. An obese person, who has struggled to lose his/ her weight, has perhaps chosen diet pills and it is probable to be frustrated with his/ her options because before the pharmaceutical industry produced weight loss medications have always been double-edged sword. Either they worked having major side effects or they did not work at all. Hoodia Diet Pills have become very successful as they do not have any side effects and work very efficiently.

Then again, hoodia diet pills lessen a person’s desire for food and thus the intake of his/ her calorie. If a person consumes lesser calories than he actually burns, then he/ she will definitely lose his/ her weight. He/ she will certainly not gain any weight if he/ she consistently maintains a ‘caloric deficit’. Products such as, Hoodia diet pills are made in such a way so that a person’s appetite is lessened and he/ she loses some redundant pounds. The Hoodia plant is responsible for the endurance of the oldest people of mankind, the San people of Africa. They executed this plant to reduce hunger during long hunting missions. This plant is proved to be dangerous or unpleasant side effects free. Researches after researches have presented this modern diet pill which is made from Hoodia Gordonii. It controls hunger through the hypothalamus by using a person’s body’s own natural messenger system to inform him/ her when, what and how much food he/ she has to have. Hoodia diet pills work for preventing weight gaining without initiating any kinds of heating or speeding of internal organs. It provides a mighty weapon to reduce hunger because having this pill, a person takes way much lesser calories.

It is true that, pure hoodia diet pills are very rare and hard to get. But, today, it is one of the most effective diet pills.

By: Wouter Van Dyck -

Article Directory: http://www.articledashboard.com

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The Cactus Diet

The Cactus Diet is easy. Hoodia Gordonii cactus will revolutionize the way you look at weight loss by curbing hunger to help you shed pounds.

Did the title of this article bring a smile to your lips or cause your eyes to widen? Just when you thought you’d seen it all… you’ve heard of the grapefruit diet, and you will never forget the lingering bitter taste in your mouth. You tried the cabbage diet, and it was enough to make you want to swear off cabbage for the rest of your life. You even tried the soup diet, the Atkins diet, the low-fat diet, and every other fill-in-the-blank diet on the market. A Cactus Diet though? No way…

Don’t worry. I’m not suggesting that you munch on a desert plant. However, that’s how the story of the Hoodia Gordonii Cactus Diet began. Although incorporating the Hoodia Gordonii cactus into your diet is a new concept, its origins date back centuries. In the 1990’s, the CSIR (Council for Scientific and Industrial Research) in Africa conducted a study on the food that the Bushmen ate. They tested different natural food sources, mostly to ensure that the foods were non-toxic. When they found the Hoodia Gordonii cactus, animal testing was ordered to determine whether the plant was toxic.

Their findings paved the way for the Hoodia Gordonii Cactus Diet, a diet that isn’t really a novel concept, but rather an old concept made easy. Since this cactus-style plant is a vegetable, it is also 100% safe and healthy. The Bushmen ate this plant during long journeys in the desert to ward off hunger. The CSIR found some interesting results after animal testing. Hoodia Gordonii Cactus was not toxic. It also caused the animals to lose weight! By 1997, the CSIR isolated P57, the ingredient responsible for the weight loss. The cactus diet was introduced to the general population in 2004.

The best thing about the Hoodia Gordonii cactus diet is that you really don’t have to do anything. There are no complicated steps to follow. There are no foods that are "off limits", and you don’t have to struggle through the diet hungry. By taking Hoodia Gordonii cactus in the pill form, you can experience what the Bushmen did. You won’t be hungry. For this reason, it will be easy to cut calories, losing weight.

The Hoodia Gordonii Cactus Diet is based on the old-fashioned, true theory that by cutting calories, you will burn off more calories than you consume. This means you will lose weight. The theory is simple, straightforward, and scientifically proven. Since Hoodia Gordonii cactus has now been introduced to the public, you can easily and safely take this in a pill form with no side effects. You’ll enjoy a feeling of well-being, diminished hunger, and better self-esteem with the knowledge that you’re finally shedding those stubborn pounds.

If you have struggled with diets in the past and are still searching for a way to transform your body, the Hoodia Gordonii cactus diet is the best option. Since you’ll merely be consuming a vegetable, there is no reason to worry that this won’t be a healthy, safe way to get the body you’ve always dreamed of. Featured on programs like 60 Minutes and Today, the Hoodia Gordonii Cactus Diet is quickly revolutionizing the world of weight loss.

Martin Stanwyck is a recognized expert on weight loss. He has written several articles on the subject. Visit www.hoodia.info.ms to learn more about his main topic Hoodia Gordonii.

By Martin Stanwyck Published: 10/11/2006

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Mary’s Weight Loss Success - How Hoodia Diet Pills Helped her Lose Weight ?

You’ve probably heard how great hoodia diet pills are for weight loss but do you really know what they are or how they work? While they can be an effective weight loss aid, they are not a miracle in a bottle.

Over the past few years, there have been advertisements for hoodia diet pills all over the place. You hear how great they are for weight loss, but chances are you really don’t know what they actually do or what they’re made out of. Hoodia gordonii is a plant that acts as a natural appetite suppressant. The hoodia plant can be found in parts of South Africa and a few other countries including the United States. While there are many varieties of hoodia, there is only one that suppresses appetite. It is called hoodia gordonii. The promise the plant holds for many dieters can now be found in many different diet supplement products. If you want help with your weight loss, the first step is to learn how hoodia supplements really work.

The main way to lose weight is to eat less calories than you burn. This is normally achieved by exercising and eating right. Companies have come out with products to help people with the diet component of their weight loss program and hoodia diet pills are one of them. While they are helpful, they aren’t dieting miracle pills. Instead, they are simply a dieting aid. You still need to do the basics of eating right and exercising. Dieters have had great success with hoodia supplements. Take Mary, for example, a real dieter who lost over 20 pounds while taking them. She knew what she was supposed to do to lose weight. She exercised and she even did a good job about eating healthy food. Unfortunately, she had a voracious appetite. She couldn’t control how much she ate; she always wanted more. While she may have been eating something healthy, she would still eat too much and go over her calorie quota for the day. This posed a problem and made losing weight almost impossible. Then Mary tried hoodia diet pills. They worked great for her because they were natural appetite suppressants. She began to notice that she didn’t need to eat nearly as much food as she once demanded. Now Mary could eat a regularly portioned meal with no effort or angst.

Since every other aspect of Mary’s dieting was sound, she soon noticed the pounds melting away. With her appetite suppressed by hoodia, she was seeing progress where there was none before. This was her way of getting the results she needed. Appetite suppression is important because you can’t have effective weight loss if you can’t stop eating. So many people have this problem. You can see it based on the larger portions in restaurants. People eat more food now than they ever did before.

Hoodia doesn’t help everyone, though. If you don’t have a problem with your appetite or the amount of food that you eat because of it, then hoodia diet pills aren’t for you. If you are an emotional eater or have other eating disorders, then hoodia will do you no good. Also keep in mind that not all hoodia supplements are the same. Although they may have hoodia in the name, some may not have any at all. In fact, most sold today are fakes! They are not regulated by the government so the companies selling them have wide latitude in the claims they make. Authentic hoodia diet pills can play an important role as part of an overall weight loss program as demonstrated by Mary’s success story. However, it’s important to keep their role in perspective. If you are expecting miracles or effortless weight loss, than don’t look to hoodia. It simply doesn’t work that way!

If you are struggling with your diet and weight loss efforts hoodia diet pills may help. Visit http://hoodiaandweightloss.com to learn everything you need to know about these popular diet supplements to see if they are right for you!

By Travis Van Slooten Published: 3/12/2008

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What is Hoodia and What does it do?

Since it hit the market in the US in 2004, Hoodia has quickly become one of the most popular weight loss tools available. This may have happened because of a clever advertising blitz or simply because word of mouth for the product has been incredible. Whatever the reason, suddenly there are millions of people who know the name Hoodia but do not know the slightest thing about it.

First, while Hoodia is a diet aid, it is not a medication. It is just a plant based product that has specific properties that make it helpful in weight loss. The drug companies may want to extract some kind of substance from Hoodia to make a drug, but as of right now, Hoodia is a purely natural plant product.

The Hoodia gordonii is the variety of the plant dieters are interested in because that is the kind that helps with hunger. This plant is a succulent — something like a cactus — and can be found in the Kalahari Desert in South Africa. When local inhabitants of this area want to go on a long trip in the desert, they need something to help them with their cravings for food. For centuries, they have been using this plant to do that very thing.

As mentioned before, Hoodia is not a drug. Another thing Hoodia is not is a stimulant. For this reason, Hoodia can be taken safely without concern about overmedicating. It does not give you the jitters like coffee does or cancer like cigarettes do. These substances are questionable in their ability to help you lose weight, but they are far less safe than Hoodia, which really works.

The way Hoodia works is by controlling the appetite. If you are a person who eats just out of habit, you might need to add behavior modification to your Hoodia use. However, it will be much easier than without Hoodia.

Whether or not you have professional help in losing weight, you will feel a variety of effects on your appetite when you use Hoodia. You will not think about food constantly, and then when you do eat, it will not take much to fill you up. It will also be longer before you want to eat again. As far as the appetite mechanism in the brain is concerned, you have already eaten.

You may be one of the lucky ones who feel the effects of Hoodia as soon as you start to take it. Others have to wait for weeks before it really kicks in. If you are patient, though, you will soon be noticing a drop in your desire to overeat. The pounds should begin to drop off. Hoodia will not solve every diet problem, but it does have a great effect on controlling hunger.

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You’ve Heard All The Hype but Does Hoodia Work?

You’ve heard all about the wonders of this seemingly miraculous diet pill, but does hoodia work? What do the studies and anecdotal evidence suggest? Find out now.

Hoodia Gordonii is a cactus-like plant found in the Kalahari Desert of South Africa. The San tribe have been eating the hoodia gordonii plant for centuries to stave off hunger during hunting trips. Just a small piece of the plant acts as a powerful appetite suppressant. It’s all natural and so far doesn’t have any side effects. It sounds like the perfect diet pill, but does hoodia work?

To answer the question we need to understand what hoodia does once it’s ingested. In theory, Hoodia works by tricking the brain, specifically the hypothalamus, into thinking you have consumed large amounts of food. As a result, the brain tells you that you are full. The active ingredient in hoodia, P57, is responsible for this trick.

When you eat, the food in your body is broken down into sugar. When the sensors in the hypothalamus recognize the sugar in your body, it shuts down your desire to eat. P57 is 10,000 more powerful than blood sugar (glucose). Without eating any food, P57 can trick your brain into thinking you have consumed large amounts of food when in fact you haven’t eaten a thing!

In theory this sounds great but does hoodia work like this in the real world? Phytopharm, an UK based pharmaceutical company, put the theory to the test in the 1990’s. The study comprised of 18 morbidly obese volunteers. Half of them were given authentic hoodia gordonii supplements and the other half were given a placebo for 15 days.

Those who were given hoodia diet pills ate 1,000 less calories each day than they had previously to the study. These volunteers made no other lifestyle changes, did not increase their exercise regimen, and were unaware of the effect hoodia was having on their appetite. They experienced a natural reduction in appetite with no effort on their part.

While this study seemed promising, experts were quick to point out that the study was too small and wasn’t peer-reviewed to provide any conclusive answers to the question, does hoodia work. Unfortunately, there have been no large-scale, peer-reviewed studies to address the question.

Most of the evidence we have today about the effectiveness of hoodia is anecdotal, and that evidence is mixed at best. Some swear by it while others say it doesn’t do anything for them. Experts say that those who don’t experience the appetite suppressing qualities of hoodia diet pills may not be getting enough hoodia gordonii - if any at all.

It’s important to take a close look at the hoodia diet pills themselves. Only supplements that contain 100% authentic hoodia gordonii have the potential to suppress appetite. You may be surprised to know that the majority of the hoodia diet pills sold today contain very little hoodia gordonii - if any at all!

Hoodia weight loss supplements, like all supplements, are unregulated. Companies that sell hoodia supplements can virtually say anything they want about their products. It’s up to you, the consumer, to do your due diligence before buying. Be sure to check the ingredients label of any hoodia product you are considering before buying.

Another way to determine if hoodia diet pills contain authentic hoodia gordonii is to look for a CITES certificate. These certificates are required by companies before they can export hoodia gordonii from South Africa. Companies that have them will display their CITES certificates on their websites.

You have to pay close attention to them, however, as some unscrupulous companies will put fakes on their websites. These are usually easy to spot. Fake certificates are usually blurred or will have parts of it whited out. Real certificates are easy to read because all the information is clearly visible.

So in the end does hoodia work? Probably, but there are only a few studies that say yes conclusively and they are small in scope and aren’t peer-reviewed. In addition, the anecdotal evidence is mixed. Some dieters swear by it while others say it doesn’t work for them.

The best way to answer the question is to try it yourself and see what results you get. Just be sure the hoodia diet pills you are taking contain authentic hoodia gordonii or you can be assured that it won’t work!

By Travis Van Slooten Published: 1/27/2007

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Yes, it’s true that the majority of the hoodia diet pills sold today are fake, but that’s not what this article is about. Consumers have always had to be careful about buying hoodia supplements to avoid being scammed, but now there may be another issue they need to think about - the potency of the supplements they’re buying.

Up until recently, supplements that contained authentic hoodia gordonii contained the wild grown variety. Today, however, most authentic hoodia supplements contain cultivated hoodia gordonii. The obvious question is what’s the difference between the two? They’re the same exact plant but one grows in the wild and the other one is commercially farmed like any other crop. The biggest difference between the two, however, may be the potency.

According to one of the largest raw hoodia importers in the world, wild grown hoodia has higher levels of the active ingredient, P57, the ingredient responsible for hoodia’s appetite suppressant benefits. The reason wild hoodia supposedly has more P57 is because it has been left to grow longer than cultivated hoodia. The hoodia gordonii plant must be left to grow for at least 5-6 years before it reaches maximum potency. The wild grown hoodia that has been used the past few years in supplements was at least five years old before it was harvested.

The cultivated hoodia that is now predominantly used in supplements is being harvested too soon, according to this hoodia importer. They claim it is being harvested after only two or three years - about three years before it reaches maximum potency. What you get in the end is a supplement that isn’t as effective as it should be.

Not all agree with this assessment, however. There are other hoodia insiders that claim the wild hoodia gordonii stock hasn’t been exhausted. Yet, other insiders I’ve spoken to say wild hoodia is indeed completely gone right now and the only hoodia available is the cultivated variety. Furthermore, these same insiders claim that the cultivated hoodia is equally as potent as wild hoodia gordonii so consumers don’t need to worry.

Who do you believe? Unfortunately, there isn’t standard testing done with hoodia diet pills to test for potency. There are tests that are done all the time by independent labs to determine if a given supplement contains authentic hoodia gordonii, but they don’t test the levels of P57. I doubt that such testing is even feasible. After all, how much would it cost to have every bottle tested for the specific levels of P57?

Regardless of who you believe in this debate there is one thing for certain - if the wild hoodia gordonii isn’t already depleted, it probably will be soon. If the majority of the supplements today don’t contain cultivated hoodia they probably will in the near future. That leads us back to the potency question. Are the hoodia supplements made today as effective as they used to be?

It appears we won’t have a conclusive answer anytime soon. I guess the only thing a consumer can do is monitor their own response to the hoodia diet pills they’re taking. If the pills don’t work as well as they used to at the same dosage, then more hoodia gordonii may need to be taken as today’s hoodia supplements may indeed be less potent than those in the past.

By: Travis Van Slooten

Article Directory: http://www.articledashboard.com

Not sure who to believe in this debate and would rather just stick with wild-grown hoodia diet pills to be sure you’re getting maximum potency? Find out which brands contain authentic wild hoodia by reading the hoodia reviews at hoodiaandweightloss.com

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