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Research and Clinical Studies on Hoodia

History of Hoodia

The Bushmen of South Africa have been consuming Hoodia Gordonii for thousands of years to control hunger during their long hunting trips. Incredibly, these people have been able to go days without eating and still remain strong and energetic after consuming Hoodia.

It is not until the mid 60’s that the first research was done on Hoodia as an appetite suppressant. Even then, it took another 30 years for South African laboratories to isolate the active appetite suppressing ingredient in Hoodia. This ingredient was called P57 and was licensed to the British pharmaceutical company - Phytopharm.

A pharmaceutical company, Pfizer learnt about Hoodia and expressed its keen interest in developing a Hoodia drug. In 1998, Phytopharm sub-licensed the rights to develop p57 to Pfizer for $21 million. Pfizer returned the rights of Hoodia to Phytopharm and the latter is now working with Unilever.
First animal study

Research on Hoodia is sparse. A 2004 study conducted by Brown University Medical School on Zucker rats (Zucker rats are special rats bred to be obese and diabetic). Injections of P57 were given into the appetite centre of rat brains. It resulted in altered levels of ATP. The rats that received Hoodia ate less, lost weight and even saw some reversal of diabetes. Anything that can stop a rat from eating is very significant! However, this was an animal study and injections in the brain are different from oral consumption, so it cannot be used to show that oral Hoodia can suppress appetite in humans.

First human trial

The first human clinical trial was conducted by Phytopharm in which volunteers were chosen from Leicester, England, and placed in a “phase 1 unit”. It was a place that had features as close to prison as it gets. Half the group was given Hoodia and the other half was given a placebo.

The results showed that there was a statistically significant reduction in caloric intake and body fat levels in the P57 group. No adverse side effects were reported in the P57 group. At the end of 15 days, the group on Hoodia had reduced their food intake by 1000 calories a day. These results our significant if one bears in mind that an average man consumes around 2,600 calories a day and a woman about 1,900. Thus, this trial study showed that the hoodia gordonii extract reduces hunger or curbs appetite.

What’s expected in future?

In 2006, Unilever announced that they were able to successfully extract Hoodia’s active ingredient in a form that could be marketed to the public. Human research trials are now ongoing and Unilever expects that a product with the active Hoodia extract will be available in 2008.

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